Hprt1tm1(Pck1-cre)Vhh
Targeted Allele Detail
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Symbol: |
Hprt1tm1(Pck1-cre)Vhh |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Volker H Haase |
MGI ID: |
MGI:3621174 |
Synonyms: |
PEPCK-Cre |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm1(Pck1-cre)Vhh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:106705
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Hprt1tm1(Pck1-cre)Vhh expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
rat |
Pck1 (362282) |
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Mutation details: The rat phosphoenolpyruvate carboxykinase 1, cytosolic promoter was used to drive expression of cre recombinase in the renal proximal tubule. The promoter was mutated in such a way that expression in the liver was reduced by 60% and increased in the kidney by 10-fold in mutant mice. The construct was inserted into ES cells lacking Hprt.
(J:106705)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pck1
(rat)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hprt1 Mutation: |
1273 strains or lines available
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Original: |
J:106705 Rankin EB, et al., Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006 Mar 1;66(5):2576-83 |
All: |
60 reference(s) |
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