Dtnb^{Gt(OST109050)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dtnb^{Gt(OST109050)Lex}
• Name: dystrobrevin, beta; gene trap OST109050, Lexicon Genetics
• MGI ID: MGI:3621006
• Synonyms: ddbn^-, Dtnb^{Gt(neo)707Lex}
• Gene: Dtnb Location: Chr12:3622381-3831796 bp, + strand Genetic Position: Chr12, 1.88 cM
• Alliance: Dtnb^{Gt(OST109050)Lex} page

Mutation origin

• Mutant Cell Line: OST109050
• Germline Transmission: Earliest citation of germline transmission: J:106640
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing sequences promoting aberrant splicing and that terminate translation and transcription of the mutated gene was inserted into intron 3, upstream of all four known alternative splice sites. Immunoblot failed to detect protein from mutant liver and kidney. (J:106640)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST109050	CG529016 ; (MGI Seq Detail)	3' RACE	Chr12:3682809-3694022 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  80 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtnb Mutation: 71 strains or lines available

References

• Original: J:106640 Grady RM, et al., Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J Neurosci. 2006 Mar 15;26(11):2841-51
• All: 2 reference(s)