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Cdkn1btm2Kin
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1btm2Kin
Name: cyclin-dependent kinase inhibitor 1B; targeted mutation 2, Kei-ichi Nakayama
MGI ID: MGI:3620550
Synonyms: p27S10A
Gene: Cdkn1b  Location: Chr6:134920401-134925513 bp, + strand  Genetic Position: Chr6, 65.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106136
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
 
Mutation detailsA targeting vector was designed to insert an S10A mutation into exon 1. A neomycin resistance gene that was included in the vector was subsequently removed via cre-mediated excision. Protein was reduced in mutant brain, thymus, spleen and testis compared to wild-type. Protein levels in liver, heart, lung and skeletal muscle were not affected by the mutation. (J:106136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  10 strains or lines available
References
Original:  J:106136 Kotake Y, et al., Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem. 2005 Jan 14;280(2):1095-102
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory