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Trhtm1Mmt
Targeted Allele Detail
Nomenclature
Symbol: Trhtm1Mmt
Name: thyrotropin releasing hormone; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:3620126
Synonyms: TRH KO
Gene: Trh  Location: Chr6:92242061-92244650 bp, - strand  Genetic Position: Chr6, 41.03 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43657
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced sequences containing codons 70-211. Northern blot analysis indicated that no detectable transcript was expressed from this allele in hypothalamus, and radioimmunoassy experiments confirmed the absence of encoded protein from homozygous mice. (J:43657)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trh Mutation:  10 strains or lines available
Notes
Mice homozygous for a targeted disruption of Trh are viable, fertile, and develop normally. They exhibit, however, a tertiary hypothyroidism with elevated TSH levels, suggesting a direct effect of TRH on pituitary thyrotrophs. Impaired insulin secretion and hyperglycemia also occur in these mice (J:43657).
References
Original:  J:43657 Yamada M, et al., Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10862-7
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory