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Targeted Allele Detail
Symbol: Ikbkgtm1Mka
Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Michael Karin
MGI ID: MGI:3620102
Synonyms: Ikkgamma-, NEMO-
Gene: Ikbkg  Location: ChrX:74393290-74453854 bp, + strand  Genetic Position: ChrX, 38.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:63054
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was created by using one of two vectors. The first vector was designed to insert a beta-lactamase cassette, a stop codon and a neomycin resistance gene in frame with the first ten codons. The second vector was designed to remove most of the coding sequence in the first exon and replace it with a beta-lactamase and neomycin resistance cassette. Western blot failed to detect protein in mutant ES cells. (J:63054)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkg Mutation:  14 strains or lines available
Original:  J:63054 Makris C, et al., Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun;5(6):969-79
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory