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Mapk14tm1Gab
Targeted Allele Detail
Nomenclature
Symbol: Mapk14tm1Gab
Name: mitogen-activated protein kinase 14; targeted mutation 1, Christopher A Gabel
MGI ID: MGI:3620096
Synonyms: p38alpha-
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60918
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct was designed to replace ~8-10 kb of sequence from phenylalanine 129 to aspartic acid 283, including the TGY dual phosphorylation site, with a neomycin resistance cassette. (J:60918)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
References
Original:  J:60918 Allen M, et al., Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000 Mar 6;191(5):859-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory