Ofd1tm1Bfra
Targeted Allele Detail
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Symbol: |
Ofd1tm1Bfra |
Name: |
OFD1, centriole and centriolar satellite protein; targeted mutation 1, Brunella Franco |
MGI ID: |
MGI:3620081 |
Synonyms: |
Ofd1delta4-5 |
Gene: |
Ofd1 Location: ChrX:165173029-165223700 bp, - strand Genetic Position: ChrX, 77.28 cM
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Alliance: |
Ofd1tm1Bfra page
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Germline Transmission: |
Earliest citation of germline transmission:
J:106035
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Parent Cell Line: |
TBV2 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exons 4 and 5 were flanked by loxP sites via homologous recombination. The Frt flanked neo cassette was removed by Flp recombinase in the ES cells. After Cre mediated recombination RT-PCR confirmed absence of these exons from transcripts in mutants and Western blot analysis failed to detect protein from recombined embryos. This allele was generated from Ofd1tm2.1Bfra
(J:106035)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ofd1 Mutation: |
14 strains or lines available
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Original: |
J:106035 Ferrante MI, et al., Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet. 2006 Jan;38(1):112-7 |
All: |
4 reference(s) |
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