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Neil1tm1Rsld
Targeted Allele Detail
Nomenclature
Symbol: Neil1tm1Rsld
Name: nei endonuclease VIII-like 1 (E. coli); targeted mutation 1, R Stephen Lloyd
MGI ID: MGI:3620011
Synonyms: neil1-
Gene: Neil1  Location: Chr9:57143256-57147034 bp, - strand  Genetic Position: Chr9, 30.89 cM, cytoband C
Neil1tm1Rsld/Neil1tm1Rsld and wild-type mouse comparison

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106077
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A PGK-neo cassette was inserted into the coding region of the locus. (J:106077)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neil1 Mutation:  0 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in homozygous mice (J:106077)

References
Original:  J:106077 Vartanian V, et al., The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1864-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory