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Tg(Myh6-Pik3ca)1Siz
Transgene Detail
Summary
Symbol: Tg(Myh6-Pik3ca)1Siz
Name: transgene insertion 1, Seigo Izumo
MGI ID: MGI:3619921
Synonyms: dnPI3K
Transgene: Tg(Myh6-Pik3ca)1Siz  Location: unknown  
Alliance: Tg(Myh6-Pik3ca)1Siz page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of the mouse alpha myosin heavy chain (Myh6) promoter and a truncated Pik3ca (p110) mutant that has Pik3rl (p85) binding domains but lacks the kinase domain. Myh6 drives the expression of the dominant-negative Pik3ca in cardiac myocytes. Immunoprecipitation and western blotting confirmed transgene expression exclusively in the heart and a lipid kinase indicated that phosphatidylinositol 3-kinase activity was decreased by 77%. (J:62707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:62707 Shioi T, et al., The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 2000 Jun 1;19(11):2537-48
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory