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Transgene Detail
Symbol: Tg(IGL-MYC)3Hm
Name: transgene insertion 3, Herbert Morse
MGI ID: MGI:3619458
Synonyms: lambda-hu-MYC, lambda-MYC
Transgene: Tg(IGL-MYC)3Hm  Location: unknown  
Strain of Origin:  C57BL/6N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(IGL-MYC)3Hm expresses 1 gene
Mutation detailsA mutant human MYC gene isolated from a Burkitt lymphoma cell line and characterized by a shift in promoter use from P2 to P1 is fused to a 12 kb human genomic DNA segment containing the intronic enhancer and other functional elements of the IGL locus control region. RT-PCR analysis of various tissues of young, lymphoma-free transgenic mice detects high levels of MYC mRNA in lymphoid tissues, but no or very low levels elsewhere. Immunoblot analysis with human MYC-specific antibodies consistently detects low levels of the protein in spleens of transgenic mice. (J:65245)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:65245 Kovalchuk AL, et al., Burkitt lymphoma in the mouse. J Exp Med. 2000 Oct 16;192(8):1183-90
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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