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Tg(Pbsn-MYC)6Key
Transgene Detail
Nomenclature
Symbol: Tg(Pbsn-MYC)6Key
Name: transgene insertion 6, Charles L Sawyers
MGI ID: MGI:3619445
Synonyms: Lo-Myc, PB-Myc-PAI
Transgene: Tg(Pbsn-MYC)6Key  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pbsn-MYC)6Key expresses 1 gene
 
Mutation detailsNucleotides -426 through +28 of the rat probasin gene, containing its androgen-inducible, prostate-specific promoter, were joined to a human MYC cDNA flanked by a FLAG epitope coding sequence and the polyadenylation signal from the insulin receptor gene. Immunoblot analysis with an antibody specific for human MYC demonstrates expression in prostate of mice as young as two weeks of age, which increases as the mice approach puberty at approximately 4 weeks. (J:85480)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:85480 Ellwood-Yen K, et al., Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep;4(3):223-38
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory