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Bub3tm1Jvd
Targeted Allele Detail
Nomenclature
Symbol: Bub3tm1Jvd
Name: BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
MGI ID: MGI:3619247
Synonyms: Bub3-
Gene: Bub3  Location: Chr7:131560370-131571895 bp, + strand  Genetic Position: Chr7, 74.36 cM
Reduced lifespan, cataract, lordokyphosis and cachexia in Bub3tm1Jvd/Bub3+ Rae1tm1Jvd/Rae1+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81546
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region was interrupted at amino acid 191 by homologous recombination. Exon 3 was replaced with a neomycin resistance gene in reverse orientation. Western blot detected the encoded protein in heterozygous mice at reduced levels. (J:81546)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bub3 Mutation:  8 strains or lines available
References
Original:  J:81546 Babu JR, et al., Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003 Feb 3;160(3):341-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory