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Targeted Allele Detail
Symbol: Rae1tm1Jvd
Name: ribonucleic acid export 1; targeted mutation 1, Jan M A van Deursen
MGI ID: MGI:3619246
Synonyms: Rae1-
Gene: Rae1  Location: Chr2:173000117-173015739 bp, + strand  Genetic Position: Chr2, 95.66 cM
Reduced lifespan, cataract, lordokyphosis and cachexia in Bub3tm1Jvd/Bub3+ Rae1tm1Jvd/Rae1+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81546
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a promoterless IRES-lacZ-neo to interrupt the coding sequence at amino acid 50. (J:81546)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rae1 Mutation:  19 strains or lines available
Original:  J:81546 Babu JR, et al., Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003 Feb 3;160(3):341-53
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory