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Targeted Allele Detail
Symbol: Sufutm1Rto
Name: suppressor of fused homolog (Drosophila); targeted mutation 1, Rune Toftgard
MGI ID: MGI:3619046
Synonyms: Sufu-
Gene: Sufu  Location: Chr19:46396896-46488804 bp, + strand  Genetic Position: Chr19, 38.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:105832
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA vector was designed to replace part of the promoter, 5' UTR and first exon, including both transcription and translation start sites, with a neomycin resistance cassette. Northern blot did not detect transcript in mutants and Western blot analysis failed to detect protein. (J:105832)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sufu Mutation:  17 strains or lines available
Original:  J:105832 Svard J, et al., Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell. 2006 Feb;10(2):187-97
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory