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Cacna1etm1.1Beck
Targeted Allele Detail
Nomenclature
Symbol: Cacna1etm1.1Beck
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1.1, Heinz Beck
MGI ID: MGI:3619022
Synonyms: Cav2.3(-)
Gene: Cacna1e  Location: Chr1:154390731-154884501 bp, - strand  Genetic Position: Chr1, 66.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105917
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neomycin cassette was inserted between exons 2 and 3 and a third loxP site was inserted upstream of exon 2. The neomycin cassette was subsequently removed from properly targeted ES cells by transient transfection with a cre expressing vector. As a result, exon 2 was flanked by loxP sites. The resulting mice were crossed with mice carrying Tg(CMV-cre)1Cgn which caused the germline excision of exon 2. (J:105917)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1e Mutation:  46 strains or lines available
References
Original:  J:105917 Sochivko D, et al., The Ca(V)2.3 Ca(2+) channel subunit contributes to R-type Ca(2+) currents in murine hippocampal and neocortical neurones. J Physiol. 2002 Aug 1;542(Pt 3):699-710
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory