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Aarssti
Spontaneous Allele Detail
Nomenclature
Symbol: Aarssti
Name: alanyl-tRNA synthetase; sticky
MGI ID: MGI:3618596
Synonyms: AarsA734E
Gene: Aars  Location: Chr8:111033144-111057664 bp, + strand  Genetic Position: Chr8, 57.9 cM
Aarssti/ Aarssti

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  Laboratory stock
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA C-to-A nucelotide change at nucleotide 2201 is predicted to result in an alanine to glutamic acid non-conservative amino acid change in codon 774 of the encoded protein. Transgenic rescue experiments using a wild-type Aars gene indicated that this transversion mutation is responsible for the mutant phenotype. (J:110647)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aars Mutation:  34 strains or lines available
Notes
The sticky mutation arose on an unknown mouse stock.
References
Original:  J:110647 Lee JW, et al., Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443(7107):50-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory