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Targeted Allele Detail
Symbol: Crebbptm1Jvd
Name: CREB binding protein; targeted mutation 1, Jan M A van Deursen
MGI ID: MGI:3618462
Synonyms: CBPflox
Gene: Crebbp  Location: Chr16:4081334-4213957 bp, - strand  Genetic Position: Chr16, 2.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:88323
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP recombination site was inserted in intron 8 and a floxed Neo-HSV tk selection cassette was inserted in intron 9. The selection cassette was then removed from correctly targeted ES cells by by transient expression of cre recombinase. (J:88323)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  18 strains or lines available
Original:  J:88323 Kang-Decker N, et al., Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004 Feb;5(2):177-89
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory