E2f6^tm1Sgau
Targeted Allele Detail

Summary

• Symbol: E2f6^tm1Sgau
• Name: E2F transcription factor 6; targeted mutation 1, Stefan Gaubatz
• MGI ID: MGI:3617817
• Synonyms: E2f6^-
• Gene: E2f6 Location: Chr12:16860932-16876753 bp, + strand Genetic Position: Chr12, 8.04 cM
• Alliance: E2f6^tm1Sgau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106219
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3-5, encompassing the dimerization and DNS-binding domains of the gene. Northern blot and Western blot confirmed absence of transcript and protein, respectively, in mutants. (J:106219)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f6 Mutation: 12 strains or lines available

References

• Original: J:106219 Storre J, et al., Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Rep. 2002 Jul;3(7):695-700
• All: 2 reference(s)