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Rad54btm1Roka
Targeted Allele Detail
Nomenclature
Symbol: Rad54btm1Roka
Name: RAD54 homolog B (S. cerevisiae); targeted mutation 1, Roland Kanaar
MGI ID: MGI:3617695
Synonyms: mRad54B-
Gene: Rad54b  Location: Chr4:11558922-11615805 bp, + strand  Genetic Position: Chr4, 5.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105544
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to remove exons 12 and 13, including 28 highly conserved amino acids spanning the last conserved SNF2/SWI2 family member motif, by replacement with a neomycin resistance cassette. Northern blot confirmed ablation of transcription in mutant mice. (J:105544)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad54b Mutation:  123 strains or lines available
References
Original:  J:105544 Wesoly J, et al., Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006 Feb;26(3):976-89
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory