Pscr1^DBA/2
QTL Variant Detail

Summary

• QTL variant: Pscr1^DBA/2
• Name: corneal resistance to P. aeruginosa 1; DBA/2
• MGI ID: MGI:3617623
• QTL: Pscr1 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers resistance to corneal infection by Pseudomonas aeruginosa compared to BALB/c and C57BL/6. (J:8914)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:8914

Inbred strain BALB/c is susceptible to corneal infection with Pseudomonas aeruginosa whereas inbred strain DBA/2 is resistant. Approximately 30% of animals from a (DBA/2 x BALB/c)F1 x BALB/c backcross exhibit the resistant phenotype indicating that at least 2 resistance loci are involved.

Analysis of several previously established congenic lines derived from BALB/c and DBA/2 mapped one resistance locus, Pscr1 (corneal resistance to P. aeruginosa 1), to mouse Chromosome 5 near Pgm1 (38 cM) and Spp1 (56 cM). A second locus named Pscr2 mapped to mouse Chromosome 1 between Idh1 (29.8 cM) and Pepc (71 cM). A potential candidate gene for Pscr2 is Slc11a1 (39.2 cM). A third locus, Pscr3, on mouse Chromosome 12 is also implicated in resistance to corneal infection by P. aeruginosa. Pscr3 may be located near Igh-Ia (58.5 cM). DBA/2-derived alleles at Pscr1, Pscr2,and Pscr3 confer resistance.

These three resistance loci were confirmed using 26 BXD recominant inbred lines where progenitor strain C57BL/6 is susceptible and progenitor strain DBA/2 is resistant. However, the 3 BXD RI strains that were homozygous for DBA/2-derived alleles on chromosome 1, 5, and 12 exhibit partial resistance to corneal infection by P. aeruginosa.

References

• Original: J:8914 Berk RS, et al., Genetic studies on resistant and susceptibility genes controlling the mouse cornea to infection with Pseudomonas aeruginosa. Antibiot Chemother. 1987;39:83-91
• All: 1 reference(s)