Sostdc1^tm1Myan
Targeted Allele Detail

Summary

• Symbol: Sostdc1^tm1Myan
• Name: sclerostin domain containing 1; targeted mutation 1, Motoko Yanagita
• MGI ID: MGI:3617495
• Synonyms: USAG1^-
• Gene: Sostdc1 Location: Chr12:36364168-36368451 bp, + strand Genetic Position: Chr12, 16.82 cM, cytoband B2
• Alliance: Sostdc1^tm1Myan page

Sostdc1^tm1Myan/Sostdc1^tm1Myan Col4a3^tm1Dec/Col4a3^tm1Dec mice show less glomerular and tubular injury than Col4a3^tm1Dec/Col4a3^tm1Dec mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a nuclear lacZ gene and neo cassette. The transcription initiation codon, signal peptide and the following 46 amino acids were removed. Northern blot analysis failed to detect transcript in kidney samples from homozygous mutants. (J:105264)

Expression

In Mice Carrying this Mutation:	118 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sostdc1 Mutation: 28 strains or lines available

References

• Original: J:105264 Yanagita M, et al., Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. J Clin Invest. 2006 Jan;116(1):70-9
• All: 8 reference(s)