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Targeted Allele Detail
Symbol: Dclk1tm1.1Jgg
Name: doublecortin-like kinase 1; targeted mutation 1.1, Joseph G Gleeson
MGI ID: MGI:3617379
Synonyms: Dclk-
Gene: Dclk1  Location: Chr3:55242364-55539068 bp, + strand  Genetic Position: Chr3, 26.53 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:105300
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre mediated recombination was used to remove exon 3. Removal of this exon is predicted to result in splicing of exon 2 to a downstream exon, resulting in out-of-frame splicing. Exon 3 encodes the majority of the R1 repeat. Mutants demonstrated abolishment of isoforms containing the DCX domain. (J:105300)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dclk1 Mutation:  22 strains or lines available
Original:  J:105300 Koizumi H, et al., Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron. 2006 Jan 5;49(1):55-66
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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