Egm2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Egm2^DBA/2J
• Name: egg modifier locus 2; DBA/2J
• MGI ID: MGI:3617343
• QTL: Egm2 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:47082

Female animals from 25 BXD (B=C57BL/6J;D=DBA/2J) recombinant inbred (RI) strains were mated with (C57BL/6J x DBA/2J)F1 males and the fertilized eggs were subjected to nuclear transplantation to create androgenetic and gynogenetic embryos. The frequency of androgenetic blastocyst formation was measured. Eggs from parental strain C57BL/6J supports a significantly higher rate of androgenetic blastocyst formation compared to eggs from DBA/2J (50% vs 6%).

The analysis of the SDPs in the BXD RI lines was informative to show the Egm2 (egg modifier locus 2) phenotype was associated with mouse Chromosome 2 markers D2Mit14a (48.5 cM), Mdk (53 cM), D2Nds1 (53 cM) and D2Mit12 (53 cM). Therefore, the QTL interval of Egm2 is limited to 48.5 cM - 53 cM. The following strains were DBA/2J-like - 5, 12, 19, 20, 21, and 29, the rest with the exception of strain 13 were C57BL/6J-like. The strain distribution supports a two locus model with another region associated with Chromosome 1 named Egm1 (egg modifier locus 1).

References

• Original: J:47082 Latham KE, et al., Localization of genes encoding egg modifiers of paternal genome function to mouse chromosomes one and two. Development. 1998 Mar;125(5):929-35
• All: 1 reference(s)