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Pkd1tm2.1Ggg
Targeted Allele Detail
Nomenclature
Symbol: Pkd1tm2.1Ggg
Name: polycystin 1, transient receptor poteintial channel interacting; targeted mutation 2.1, Gregory G Germino
MGI ID: MGI:3617325
Synonyms: Pkd1del2-4
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103719
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated by breeding mice carrying Pkd1tm2Ggg with Meox2tm1(cre)Sor mice that express cre in the germline. Cre-mediated recombination removed exons 2 to 4. RT-PCR shows that mutant transcripts lack exons 2-4. (J:103719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  99 strains or lines available
References
Original:  J:103719 Piontek KB, et al., A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004 Dec;15(12):3035-43
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory