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Gcktm1Hrt
Targeted Allele Detail
Nomenclature
Symbol: Gcktm1Hrt
Name: glucokinase; targeted mutation 1, Huan-ran Tan
MGI ID: MGI:3615946
Synonyms: gklox
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105247
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites were inserted to flank exons 9 and 10 with a third loxP site flanking a neo gene. (J:105247)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  37 strains or lines available
References
Original:  J:105247 Zhang YL, et al., Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs. Acta Pharmacol Sin. 2004 Dec;25(12):1659-65
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory