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Tg(Atoh1-cre/Esr1*)14Fsh
Transgene Detail
Nomenclature
Symbol: Tg(Atoh1-cre/Esr1*)14Fsh
Name: transgene insertion 14, Gordon Fishell
MGI ID: MGI:3615691
Synonyms: Atoh1-cre, Math1-cre, Math1-CreERT2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh
Transgene: Tg(Atoh1-cre/Esr1*)14Fsh  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex). (J:105186)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Atoh1     Summary of all recombinase alleles driven by Atoh1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:105186 Machold R, et al., Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron. 2005 Oct 6;48(1):17-24
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory