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Targeted Allele Detail
Symbol: Dsc3tm1Pko
Name: desmocollin 3; targeted mutation 1, Peter J Koch
MGI ID: MGI:3615340
Synonyms: Dsc3-
Gene: Dsc3  Location: Chr18:19960930-20002351 bp, - strand  Genetic Position: Chr18, 11.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:105239
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed PGK-neo cassette replaced part of the promoter, exon 1 (containing the start codon) and intron 1. Quantitative PCR and Western blot analysis demonstrated that expression in heterozygous mice is half that of wild-type mice. (J:105239)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dsc3 Mutation:  3 strains or lines available
Original:  J:105239 Den Z, et al., Desmocollin 3 is required for pre-implantation development of the mouse embryo. J Cell Sci. 2006 Feb 1;119(Pt 3):482-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory