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Obq21SM/J
QTL Variant Detail
Summary
QTL variant: Obq21SM/J
Name: obesity QTL 21; SM/J
MGI ID: MGI:3614949
QTL: Obq21  Location: unknown  Genetic Position: Chr18, cM position of peak correlated region/allele: 57.53 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  SM/J
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obq21 maps to 54 cM on mouse Chromosome 18 near D18Mit4 (LOD=2.5) with a 95% confidence interval spanning approximately 22 cM - 56 cM. NZB/BlNJ-derived alleles at Obq21 confer increased retroperitoneal fat pad weight with a dominant mode of inheritance.

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory