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QTL Variant Detail
QTL variant: Obq20NZB/BlNJ
Name: obesity QTL 20; NZB/BlNJ
MGI ID: MGI:3614889
QTL: Obq20  Location: unknown  Genetic Position: Chr8, cM position of peak correlated region/allele: 2.14 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  NZB/BlNJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased inguinal and gonadal fat pad weights compared to SM/J. (J:103841)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
Obq20 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obq20 maps to 0 cM on mouse Chromosome 8 near D8Mit155 (LOD=3.2) with a 95% confidence interval spanning approximately 0 cM - 20 cM. NZB/BlNJ-derived alleles at Obq20 confer increased inguinal and gonadal fat pad weights with an additive mode of inheritance.

Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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