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Obq20NZB/BlNJ
QTL Variant Detail
Nomenclature
QTL variant: Obq20NZB/BlNJ
Name: obesity QTL 20; NZB/BlNJ
MGI ID: MGI:3614889
QTL: Obq20  Location: unknown  Genetic Position: Chr8, cM position of peak correlated region/allele: 2.14 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased inguinal and gonadal fat pad weights compared to SM/J. (J:103841)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Obq20 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obq20 maps to 0 cM on mouse Chromosome 8 near D8Mit155 (LOD=3.2) with a 95% confidence interval spanning approximately 0 cM - 20 cM. NZB/BlNJ-derived alleles at Obq20 confer increased inguinal and gonadal fat pad weights with an additive mode of inheritance.

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory