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Bwtq11NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Bwtq11NZB/BlNJ
Name: body weight QTL 11; NZB/BlNJ
MGI ID: MGI:3614881
QTL: Bwtq11  Location: unknown  Genetic Position: Chr12, Syntenic
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increase lean body weight compared to SM/J. (J:103841)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Bwtq11 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 12, Adip16 maps to 26 cM near D12Mit91 (LOD=5.3) with a 95% confidence intervals spanning 12 cM -32 cM. SM/J-derived alleles at Adip16 confer increased inguinal and gonadal fat pad weights with a dominant mode of inheritance. Previously identified obesity QTL Afpq10 (18 cM), Afw10 (21 cM), Fob2 (19 cM), and Mob3 (53 cM) map near the Adip16 interval.

Bwtq11 maps to 54 cM on mouse Chromosome 12 near D12Mit19 (LOD=4.3) with a 95% confidence interval spanning approximately 42 cM - 58 cM. NZB/BlNJ-derived alleles at Bwtq12 confer increased lean body weight with an additive mode of inheritance. Previously identified adiposity QTL Adip6 (45 cM) maps near Bwtq11.

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory