Pmp22^tm1Lnot
Targeted Allele Detail

Summary

• Symbol: Pmp22^tm1Lnot
• Name: peripheral myelin protein 22; targeted mutation 1, Lucia Notterpek
• MGI ID: MGI:3614822
• Gene: Pmp22 Location: Chr11:63019808-63050373 bp, + strand Genetic Position: Chr11, 38.99 cM
• Alliance: Pmp22^tm1Lnot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Velocigene technology was used to insert a cassette containing a lacZ-stop-PGK-noe-stop cassette immediately downstream of the ATG in exon 2, subsequently replacing the rest of exon 2 and all of exon 3. Western blot did not detect protein in mutant sciatic nerve lysates. Beta-gal expression was detected widely in the E15 mouse embryo. (J:104989)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmp22 Mutation: 32 strains or lines available

References

• Original: J:104989 Amici SA, et al., Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J Neurosci. 2006 Jan 25;26(4):1179-89
• All: 3 reference(s)