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Targeted Allele Detail
Symbol: Pmp22tm1Lnot
Name: peripheral myelin protein 22; targeted mutation 1, Lucia Notterpek
MGI ID: MGI:3614822
Gene: Pmp22  Location: Chr11:63128982-63159547 bp, + strand  Genetic Position: Chr11, 38.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:104989
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsVelocigene technology was used to insert a cassette containing a lacZ-stop-PGK-noe-stop cassette immediately downstream of the ATG in exon 2, subsequently replacing the rest of exon 2 and all of exon 3. Western blot did not detect protein in mutant sciatic nerve lysates. Beta-gal expression was detected widely in the E15 mouse embryo. (J:104989)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pmp22 Mutation:  18 strains or lines available
Original:  J:104989 Amici SA, et al., Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J Neurosci. 2006 Jan 25;26(4):1179-89
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory