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Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
Transgene Detail
Nomenclature
Symbol: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
Name: transgene insertion Db-1, William Muller
MGI ID: MGI:3614340
Synonyms: MMTV/MT-Y315/322F, MMTV-PyVmT Y315/322F, Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul
Transgene: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene expresses mutant plyomavirus middle T antigen with Y to F mutation at position 315 and 322 under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. (J:56327)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Total of 7 lines were produced, of which six lines Db-1, Db-3, Db-4, Db-5, Db-6 and Db-7 had similar phenotype. These mice were used to study metastatic disease and they had similar phenotype.

References
Original:  J:56327 Webster MA, et al., Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol. 1998 Apr;18(4):2344-59
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory