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Targeted Allele Detail
Symbol: F10tm1Edr
Name: coagulation factor X; targeted mutation 1, Elliot D Rosen
MGI ID: MGI:3613747
Synonyms: FX-
Gene: F10  Location: Chr8:13037308-13056676 bp, + strand  Genetic Position: Chr8, 5.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:61230
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 18kb of sequence including exons 2-8, which encode the mature protein. RT-PCR analysis did not detect transcript in liver from homozygous E17.5 mutant embryos. Immunohistochemical analysis did not detect protein in liver sections from homozygous E17.5 mutant embryos. (J:61230)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F10 Mutation:  19 strains or lines available
Original:  J:61230 Dewerchin M, et al., Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000 Feb;83(2):185-90
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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