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Baxtm1Ofxa
Targeted Allele Detail
Nomenclature
Symbol: Baxtm1Ofxa
Name: BCL2-associated X protein; targeted mutation 1, Osborne FX Almeida
MGI ID: MGI:3613737
Synonyms: bax -
Gene: Bax  Location: Chr7:45461697-45466898 bp, - strand  Genetic Position: Chr7, 29.32 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61471
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a lacZ gene and an RSV-neomycin resistance cassette replaced most of the protein coding sequence in the first four exons. Western blot analysis did not detect protein in hippocampi from homozygous mutant mice. (J:61471)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bax Mutation:  21 strains or lines available
References
Original:  J:61471 Almeida OF, et al., Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 2000 Apr;14(5):779-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory