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Arhgdiatm1Ytk
Targeted Allele Detail
Nomenclature
Symbol: Arhgdiatm1Ytk
Name: Rho GDP dissociation inhibitor (GDI) alpha; targeted mutation 1, Yoshimi Takai
MGI ID: MGI:3613573
Synonyms: Rho GDIalpha -
Gene: Arhgdia  Location: Chr11:120578104-120581624 bp, - strand  Genetic Position: Chr11, 84.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57995
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3kb MC1-neomycin resistance cassette replaced all three exons. Western blot analysis did not detect protein in spleen lysates from homozygous mutant mice. (J:57995)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgdia Mutation:  13 strains or lines available
References
Original:  J:57995 Togawa A, et al., Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene. 1999 Sep 23;18(39):5373-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory