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Targeted Allele Detail
Symbol: Tnfsf12tm1Ash
Name: tumor necrosis factor (ligand) superfamily, member 12; targeted mutation 1, Avi Ashikenazi
MGI ID: MGI:3613442
Synonyms: TWEAK-, TWEAK-KO
Gene: Tnfsf12  Location: Chr11:69686250-69695849 bp, - strand  Genetic Position: Chr11, 42.86 cM, cytoband B4
Germline Transmission:  Earliest citation of germline transmission: J:104801
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace 2.5 kb of the locus, encompassing the first exon and all five downstream exons, with a PGK-neo cassette. Quantitative RT-PCR failed to detect transcript in mutants. (J:104801)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf12 Mutation:  112 strains or lines available
Original:  J:104801 Maecker H, et al., TWEAK attenuates the transition from innate to adaptive immunity. Cell. 2005 Dec 2;123(5):931-44
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory