Plec^tm3Gwi
Targeted Allele Detail

Summary

• Symbol: Plec^tm3Gwi
• Name: plectin; targeted mutation 3, Gerhard Wiche
• MGI ID: MGI:3613062
• Gene: Plec Location: Chr15:76055174-76115578 bp, - strand Genetic Position: Chr15, 35.48 cM
• Alliance: Plec^tm3Gwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104701
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked cassette containing an EGFP and a floxed neo was inserted to replace exon 1. Ablation of isoform 1 was confirmed by immunoblot. The other isoforms were expressed. (J:104701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plec Mutation: 173 strains or lines available

References

• Original: J:104701 Abrahamsberg C, et al., Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18449-54
• All: 3 reference(s)