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Wfs1tm1Perm
Targeted Allele Detail
Nomenclature
Symbol: Wfs1tm1Perm
Name: wolframin ER transmembrane glycoprotein; targeted mutation 1, M A Permutt
MGI ID: MGI:3613056
Synonyms: Wfs1fl
Gene: Wfs1  Location: Chr5:36966104-36989205 bp, - strand  Genetic Position: Chr5, 19.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104712
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exon 8, which encodes the transmembrane domain and two-thirds of the protein. (J:104712)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wfs1 Mutation:  25 strains or lines available
References
Original:  J:104712 Riggs AC, et al., Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia. 2005 Nov;48(11):2313-21
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory