Txnip^tm1Jjy
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1Jjy
• Name: thioredoxin interacting protein; targeted mutation 1, Junji Yodoi
• MGI ID: MGI:3613036
• Synonyms: TBP-2^-
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1Jjy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104563
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 1-4. Absence of transcript in mutant heart, thymus, spleen, liver and muscle was confirmed by Northern blot. (J:104563)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 48 strains or lines available

References

• Original: J:104563 Oka S, et al., Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J. 2006 Jan;20(1):121-3
• All: 5 reference(s)