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Dio1tm1Vag
Targeted Allele Detail
Nomenclature
Symbol: Dio1tm1Vag
Name: deiodinase, iodothyronine, type I; targeted mutation 1, Valerie Anne Galton
MGI ID: MGI:3613031
Synonyms: D1KO
Gene: Dio1  Location: Chr4:107291465-107307169 bp, - strand  Genetic Position: Chr4, 50.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104508
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon two, containing the TGA selenocysteine codon, was replaced with the neo cassette. Protein activity was not detected in mutant liver, kidney, thyroid or pituitary tissues. (J:104508)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dio1 Mutation:  4 strains or lines available
Notes
ES cell line = DS2A
References
Original:  J:104508 Schneider MJ, et al., Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology. 2006 Jan;147(1):580-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory