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Als2tm1Jei
Targeted Allele Detail
Nomenclature
Symbol: Als2tm1Jei
Name: amyotrophic lateral sclerosis 2 (juvenile); targeted mutation 1, Joh-E Ikeda
MGI ID: MGI:3612978
Synonyms: Als2-, Als2tm1Jeo
Gene: Als2  Location: Chr1:59162926-59237231 bp, - strand  Genetic Position: Chr1, 29.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104446
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Als2 Mutation:  21 strains or lines available
Notes
In J:104446, the authors state that despite the lack of phenotypic similarity to human ALS2 disease, these mice may be useful models for investigating the molecular pathogenesis of motorneuron diseases arising from ALS2 mutations.

References
Original:  J:104446 Hadano S, et al., Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. Hum Mol Genet. 2006 Jan 15;15(2):233-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory