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Btktm1Witt
Targeted Allele Detail
Nomenclature
Symbol: Btktm1Witt
Name: Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1, Owen N Witte
MGI ID: MGI:3612416
Synonyms: Btk Y375F
Gene: Btk  Location: ChrX:134542336-134583570 bp, - strand  Genetic Position: ChrX, 56.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104167
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a Y375F mutation into exon 13. Mutant mice showed normal B cell development and function. (J:104167)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btk Mutation:  8 strains or lines available
References
Original:  J:104167 Guo S, et al., Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. Int Immunol. 2006 Jan;18(1):79-87
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory