Btk^tm1Witt
Targeted Allele Detail

Summary

• Symbol: Btk^tm1Witt
• Name: Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1, Owen N Witte
• MGI ID: MGI:3612416
• Synonyms: Btk Y375F
• Gene: Btk Location: ChrX:133443085-133484319 bp, - strand Genetic Position: ChrX, 56.18 cM
• Alliance: Btk^tm1Witt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a Y375F mutation into exon 13. Mutant mice showed normal B cell development and function. (J:104167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btk Mutation: 22 strains or lines available

References

• Original: J:104167 Guo S, et al., Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. Int Immunol. 2006 Jan;18(1):79-87
• All: 1 reference(s)