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Targeted Allele Detail
Symbol: Pax9tm1Hpt
Name: paired box 9; targeted mutation 1, Heiko Peters
MGI ID: MGI:3612401
Synonyms: Pax9neo
Gene: Pax9  Location: Chr12:56691767-56712822 bp, + strand  Genetic Position: Chr12, 24.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:104121
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neomycin resistance cassette was inserted into intron 2. loxP sites were inserted to flank exons 1 and 2. RT-PCR and sequencing revealed the presence of alternatively spliced forms resulting from the splicing of paired box-containing exon 2 to the 3' region of the Pgk1 promoter. With the neo coding region in frame with exon 2 of Pax9, translation of the mRNA predicts and aberrant fusion protein containing the paired domain and the full-length neomycin phosphotransferase, but lacking most of the C-terminal of Pax9. (J:104121)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax9 Mutation:  8 strains or lines available
Original:  J:104121 Kist R, et al., Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia. Hum Mol Genet. 2005 Dec 1;14(23):3605-17
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory