Pkd1tm1Ggg
Targeted Allele Detail
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Symbol: |
Pkd1tm1Ggg |
Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Gregory G Germino |
MGI ID: |
MGI:3612339 |
Synonyms: |
Pkd1-, Pkd1Beta-gal null, Pkd1Betagal-null |
Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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Alliance: |
Pkd1tm1Ggg page
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Osteopenia in newborn Pkd1tm1Ggg/Pkd1tm2Ggg Tg(Col1a1-cre)1Bek/0 mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:76062
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Most of exon 2 and all of exon 3 were replaced with lacZ gene in frame to the 5' end of exon 2. This is a true null allele because of transcription termination after the beta-galactosidase gene. lacZ expression is driven by the endogenous promoter.
(J:76062, J:103719)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pkd1 Mutation: |
153 strains or lines available
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Original: |
J:76062 Bhunia AK, et al., PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell. 2002 Apr 19;109(2):157-68 |
All: |
18 reference(s) |
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