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Fscn2tm1Sykk
Targeted Allele Detail
Nomenclature
Symbol: Fscn2tm1Sykk
Name: fascin actin-bundling protein 2; targeted mutation 1, Shunji Yokokura
MGI ID: MGI:3612337
Synonyms: Fscn2p neo(-)
Gene: Fscn2  Location: Chr11:120361534-120368168 bp, + strand  Genetic Position: Chr11, 84.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103713
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA fragment lacking a guanine at nucleotide 208 of the gene replaced the endogenous sequence by homologous recombination. Cre mediated recombination removed a floxed neomycin selection cassette. RT-PCR did not detect transcript using primers designed to amplify sequence downstream of the deleted guanine. (J:103713)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fscn2 Mutation:  8 strains or lines available
References
Original:  J:103713 Yokokura S, et al., Targeted disruption of FSCN2 gene induces retinopathy in mice. Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2905-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory