Rxrb^tm1Rev
Targeted Allele Detail

Summary

• Symbol: Rxrb^tm1Rev
• Name: retinoid X receptor beta; targeted mutation 1, Ronald M Evans
• MGI ID: MGI:3612281
• Synonyms: RXRgamma^-
• Gene: Rxrb Location: Chr17:34250786-34257373 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Rxrb^tm1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51892
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette replaced part of intron 2, the splicing acceptor and part of exon 3. Transcript was not detected by Northern blot analysis of mutant organ samples. RT-PCR confirmed absence of mRNA. (J:51892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxrb Mutation: 26 strains or lines available

References

• Original: J:51892 Chiang MY, et al., An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron. 1998 Dec;21(6):1353-61
• All: 3 reference(s)