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Atg5tm1Nmz
Targeted Allele Detail
Nomenclature
Symbol: Atg5tm1Nmz
Name: autophagy related 5; targeted mutation 1, Noboru Mizushima
MGI ID: MGI:3612279
Synonyms: Atg5-
Gene: Atg5  Location: Chr10:44268358-44364291 bp, + strand  Genetic Position: Chr10, 23.24 cM
absence of otoconia (right) or the presence of giant and abnormally shaped otoconial crystals (middle) in the utricle of Atg4bGt(A029E06)Wrst/Atg4bGt(A029E06)Wrst mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70539
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 2 and 3, including the transcription start site. Protein was not detected in mutant ES cells by immunoblot analysis. (J:104491)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atg5 Mutation:  19 strains or lines available
References
Original:  J:70539 Mizushima N, et al., Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol. 2001 Feb 19;152(4):657-68
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory