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QTL Variant Detail
QTL variant: mct1C57BL/6J
Name: modifier of curly tail 1; C57BL/6J
MGI ID: MGI:3612267
Synonyms: mct1STOCK ct/J
QTL: mct1  Location: unknown  Genetic Position: Chr17, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
J:29366 penetrance of ct mutation (versus 38% on STOCK): C57BL/6J (18.50%), BXD-8/Ty (17.73%), BALB/cByJ (7.90%), M. spretus (2.50%), CAST/Ei (0%) and MOLF/Ei (0%).

Mapping and Phenotype information for this QTL, its variants and associated markers


(M. spretus x STOCK-ct/ct)F1 x STOCK-ct/ct and (BALB/cByJ x STOCK-ct/ct)F1 x STOCK-ct/ct interspecific backcross progeny were genotyped using 70 SSCP markers on 19 autosomes in a genome wide scan in an attempt to identify loci which modify the ct (curly tail) phenotype. Curly tail is coded for by a locus on mouse Chromosome 4. Various statistical parameters were used to identify a region of mouse Chromosome 17 that modified the ct phenotype. Authors have named this recessive locus mct1, modifier of curly-tail 1. By combining progeny from the two backcrosses an order of loci on mouse Chromosome 17 was indicated as: D17Mit113 - D17Mit134 - mct1 - D17Mit11 - D17Mit6 - D17Mit3 - D17Mit72 - D17Mit123.

Original:  J:29366 Letts VA, et al., A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics. 1995 Oct 10;29(3):719-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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