Adra1d^tm1Jabl
Targeted Allele Detail

Summary

• Symbol: Adra1d^tm1Jabl
• Name: adrenergic receptor, alpha 1d; targeted mutation 1, Julie A Blendy
• MGI ID: MGI:3612161
• Synonyms: alpha1d^-
• Gene: Adra1d Location: Chr2:131387770-131404203 bp, - strand Genetic Position: Chr2, 63.5 cM
• Alliance: Adra1d^tm1Jabl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector containing a lacZ-neomycin resistance gene was inserted into exon 1. RNAse protection assay confirmed ablation of the gene. Immunohistochemical analysis detected beta-gal expression in the olfactory bulb, cortex, hippocampus, and dorsal geniculate and ventral posterolateral nuclei of the thalamus. (J:103966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adra1d Mutation: 30 strains or lines available

References

• Original: J:103966 Sadalge A, et al., alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity. Mol Psychiatry. 2003 Jul;8(7):664-72
• All: 2 reference(s)