Cxv2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cxv2^DBA/2J
• Name: control of xenotropic virus 2; DBA/2J
• MGI ID: MGI:3612096
• QTL: Cxv2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers high expression of xenotropic murine leukemia virus associated cell surface antigen (XenCSA) in thymocytes and spleen cells compared to C57BL/6J. (J:6143)
• Inheritance: Semidominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6143

Inbred strain DBA/2J displays high expression of xenotropic murine leukemia virus associated cell surface antigens (XenCSA) in thymocytes and spleen cells compared to inbred strain C57BL/6J. Analysis of 24 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains mapped a locus named Cxv2 (control of xenotropic virus 2) to mouse Chromosome 4 near Fv1 (76.5 cM) and centromeric to H6pd (formerly Gpd1; 78.4 cM). The estimated distance between Fv1 and Cxv2 is 7 cM. DBA/2J-derived alleles at Cxv2 is associated with high expression of XenCSA in thymocytes and spleen cells. Analysis of (C57BL/6J x DBA/2J)F1 x DBA/2J backcross animals confirmed the effect of Cxv2.

References

• Original: J:6143 Morse HC 3rd, et al., Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6. J Exp Med. 1979 May 1;149(5):1183-96
• All: 1 reference(s)